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17Alpha-羟基黄体酮

17Alpha-羟基黄体酮

CAS号：68-96-2

英文名：17α-hydroxyprogesterone

分子式

C21H30O3

熔点

276°C

密度

1.15 g/cm3

分子量

330.461

沸点

482.9ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

17α-Hydroxyprogesterone (17α-OHP), or hydroxyprogesterone (OHP) (INN, BAN), also known as 17α-hydroxypregn-4-ene-3,20-dione, is an endogenous progestogen steroid hormone related to progesterone. It is also a chemical intermediate in the biosynthesis of many other endogenous steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids.

基本信息

中文名称

17Alpha-羟基黄体酮

英文名称

17α-hydroxyprogesterone

中文别名

17a-羟基黄体酮、17-alpah-羟基黄体酮、17α-羟孕酮、17Alpha-羟基孕酮、17-ALPHA-羟基孕酮、17a-羟基-黄体酮、羟孕酮、17Α-羟基孕甾酮、17α-羟基孕甾-4-烯-3,20-二酮、17α-羟基孕酮、羟黄酮、17Alpha-羟孕酮

英文别名

Pregn-4-ene-3,20-dione, 17-hydroxy-、17α-Hydroxyprogesterone、17alpha-Hydroxyprogesterone、17alpha-hydroxyprogesterone

CAS号

68-96-2

分子式

C21H30O3

分子量

330.461

精确质量

330.219

PSA

54.37

LOGP

3.6943

编号系统

MDL号

MFCD00003659

物化性质

外观与性状

白色固体

密度

1.15 g/cm3

沸点

482.9ºC at 760 mmHg

熔点

276°C

闪点

259.9ºC

折射率

90 ° (C=1, CHCl3)

储存条件

-20ºC Freezer

安全信息

RTECS号

TU5060000

安全说明

S53-S22-S36/37/39-S45

WGK Germany

3

危险类别码

R61

危险品标志

T

生产方法及用途

用途

制药工业上主要用作安宫黄体酮、甲地孕酮等原药的中间体。

合成路线

共找到19条合成路线 >

黄体酮

17Alpha-羟基黄体酮

17Alpha-羟基黄体酮

去氧皮质酮

去氧皮质酮

皮质甾酮

脱氧可的松

脱氧可的松

上游原料

共找到45个上游原料 >

重氮甲烷

脱氧可的松

脱氧可的松

表雄酮

异丙醇铝

下游产品

共找到18个下游商品 >

(8R,9S,10R,13S,14S,17R)-17-acetyl-4-chloro-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

(8R,9S,10R,13S,14S,17R)-17-acetyl-4-chloro-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

17β-hydroxyandrostan-3-one

17β-hydroxyandrostan-3-one

17alpha-羟基孕甾-5-烯-3,20-二酮-3,20-二(乙烯缩酮)

17alpha-羟基孕甾-5-烯-3,20-二酮-3,20-二(乙烯缩酮)

17Alpha-羟基妊娠烯醇酮

17Alpha-羟基妊娠烯醇酮

孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯

孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯

上游原料

重氮甲烷脱氧可的松溴表雄酮异丙醇铝氯仿 16,17-环氧黄体酮甲苯 cyclic-3-(1,2-ethanediylmercapto)-17α-hydroxypregn-4-en-20-one 甲基锂对硝基甲苯 16,17-alpha环氧孕烯醇酮 17-hydroxy-2ξ-iodo-pregn-4-ene-3,20-dione 孕烯醇酮巯基乙酸 17α-hydroxypregn-4-en-20-yn-3-one 甲基溴化镁 (8R,10R,13S,Z)-10,13-dimethyl-17-(1-((tripropylsilyl)oxy)ethylidene)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one 17Alpha-羟基妊娠烯醇酮 5-Pregnen-3.β.,17.α.-diol-20-one-16.β.-bromo 5,6β-dichloro-3β,17-dihydroxy-5α-pregnan-20-one 17α-hydroxy-21-[(methylsulfonyl)oxy]pregn-4-ene-3,20-dione 3β,20βF-diacetoxy-pregnen-(5)-ol-(17) 4-孕烯-17Alpha,20Alpha-二醇- 3 -酮 20,20-ethanediyldioxy-pregn-5-ene-3β,17-diol 雄烯二酮 3,3-Ethylenedioxy-17α-hydroxy-androst-5-ene-17β-carbonitrile 氯化汞(II) 17α-hydroxy-21-chloro-4-pregnene-3,20-dione 甲醇黄体酮 16-去氢黄体酮 17-hydroxy-16β-iodo-pregn-4-ene-3,20-dione 3beta,17-二羟基孕甾-5-烯-20-酮 3-甲酸酯 pregnadien-(4.17(20)t)-one-(3) 3,5-pregnadien-3,17-diol-20-one-3-methyl ether 17-羟基孕甾烷e-3,20-二酮 (20S)-5α-Chloro-3β-hydroxypregnane-20-carboxaldehyde 5α-Chloro-3β,17α-dihydroxypregnan-20-one (3beta)-3-(甲酰氧基)-20-氧代孕甾-5-烯-17-基乙酸酯 20ξ-acetylamino-17,20ξ-epoxy-pregn-4-en-3-one (8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate 环己酮 3β-acetoxy-5-chloro-17,20ξ-epoxy-20ξ-formyloxy-5α-pregnane

下游产品

(8R,9S,10R,13S,14S,17R)-17-acetyl-4-chloro-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 17β-hydroxyandrostan-3-one 17alpha-羟基孕甾-5-烯-3,20-二酮-3,20-二(乙烯缩酮) 17Alpha-羟基妊娠烯醇酮睾酮孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯脱氧可的松雄烯二酮 11beta,17alpha-二羟基-4-孕烯-3,20-二酮 6beta,17alpha-二羟基黄体酮 17Alpha-羟基孕甾-4-烯-3,11,20-三酮去氧皮质酮氢化可的松去氧皮质酮新戊酸酯 17Alpha-羟基孕烯醇酮-17-乙酸酯 17,21-二羟基孕甾-4-烯-3,20-二酮17,21-二(乙酸酯) 4-孕烷-17α,20β-二醇-3-酮 3-乙氧基-雄甾-3,5-二烯-17-酮